The A.P.C. Viruses

Apc

How did it get its name? APC is short for adenomatous polyposis coli. The APC gene is mutated in familial adenomatous polyposis, a hereditary form of colon cancer. Carriers of APC mutations develop thousands of colon tumours, some of which inevitably progress to malignancy. Inactivating mutations in APC are also found in the large majority of sporadic colon cancers. APC is therefore an importan...

Production of pharyngoconjunctival fever in human volunteers inoculated with APC viruses.

The APC–tumor connection

Fewer phosphates but fatter axons xons are fattened by an unexpected neurofilament (NF) subunit, according to Garcia et al. (page 1011) and Rao et al. (page 1021), who find that more phosphorylation sites are not necessarily better when it comes to driving axon expansion. The radial growth-inducing subunit is one of three that make up NFs. The COOH-terminal tails of two of these subunits, NF-H ...

The importance of APC

Readers in immunology are familiar with the importance of antigen presenting cells in mounting immune responses. For the purpose of this particular editorial article, however, the abbreviation APC will stand for article processing charges. The publisher will introduce APCs for this Journal in May, 2005. Here we explain why article-processing charges are important to maintain our Open Access jou...

The ABC of APC.

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease characterized by the presence of adenomatous polyps in the colon and rectum, with inevitable development of colorectal cancer if left untreated. FAP is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Somatic mutations in the APC gene are an early event in colorectal tumorigenesis, and can ...